Search results for "Polycarpaea corymbosa"

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Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst.

2013

Abstract Four triterpenoid saponins (1–4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3–5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.

biologyChemistryCaryophyllaceaeTumor cellsCaryophyllaceaePlant ScienceGeneral MedicineHorticultureSaponinsbiology.organism_classificationBiochemistryAntineoplastic Agents PhytogenicTriterpenesInhibitory Concentration 50TriterpenoidDU145Cell Line TumorPolycarpaea corymbosaBotanyIc50 valuesHumansCytotoxicityMolecular BiologyPhytochemistry

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